| DATE | OPPONENT | SCORE | RECORD/BIG 12 |
| Nov 5 | Athletes First (Exh) | W 86-78 | 1-0 |
| Nov 9 | EA Sports (Exh) | 85-56 | 2-0 |
| Nov 12 | Central Connecticut Preseason NIT |
W 66-44 | 1-0 |
| Nov 14 | Michigan State Preseason NIT |
L 67-55 | 1-1 |
| Nov 28 | Central Michigan | W 81-64 | 2-1 |
| Dec 1 | at Arkansas | W 69-54 | 3-1 |
| Dec 5 | St. Bonaventure | W 80-74 | 4-1 |
| Dec 8 | Louisiana Tech | W 71-67 (OT) | 5-1 |
| Dec 15 | High Point (N.C.) | W 107-63 | 6-1 |
| Dec 16 | Bethune-Cookman | W 102-65 | 7-1 |
| Dec 18 | Eastern Illinois | W 109-50 | 8-1 |
| Dec 21 | Maryland | W 72-56 | 9-1 |
| Dec 29 | Texas Southern All-College Classic |
W 97-55 | 10-1 |
| Jan 5 | Texas A&M* | W 89-63 | 11-1 / 1-0 |
| Jan 7 | at Connecticut | W 69-67 | 12-1 / 1-0 |
| Jan 12 | Texas Tech* | W 98-72 | 13-1 / 2-0 |
| Jan 16 | at Nebraska* | W 78-51 | 14-1 / 3-0 |
| Jan 19 | at Kansas* | L 74-67 | 14-2 / 3-1 |
| Jan 21 | Missouri* | W 84-71 | 15-3 / 4-1 |
| Jan 26 | at Texas Tech* | L 92-79 | 15-4 / 4-2 |
| Jan 30 | Oklahoma State* | W 58-53 | 16-4 / 5-2 |
| Feb 2 | at Texas* | W 85-84 (OT) | 17-4 / 6-2 |
| Feb 6 | Baylor* | W 70-57 | 18-4 / 7-2 |
| Feb 9 | at Texas A&M* | W 68-64 | 19-4 / 8-2 |
| Feb 13 | at Oklahoma State* | L 79-72 OT | 19-5 / 8-3 |
| Feb 16 | Kansas State* | W 73-62 | 20-5 / 9-3 |
| Feb 19 | at Baylor* | W 66-54 | 21-5 / 10-3 |
| Feb 23 | Texas* | W 96-78 | 22-5 / 11-3 |
| Feb 26 | Iowa State* | W 89-75 | 23-5 / 12-3 |
| Mar 2 | at Colorado* | W 82-71 | 24-5 / 13-3 |
| Mar 7 | Bye Round 1 - Big 12 Tournament |
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| Mar 8 | Kansas State* Round 2 - Big 12 Tournament |
W 63-52 | 25-5 / 14-3 |
| Mar 9 | Texas* Round 3 - Big 12 Tournament |
W 67-51 | 26-5 / 15-3 |
| Mar 10 | Kansas Championship - Big 12 Tournament |
W 64-55 | 27-5 / 16-3 |
| Mar 15 | Illinois-chicago NCAA First Round |
W 71-63 | 28-5 / 16-3 |
| Mar 17 | Xavier NCAA Second Round |
W 78-65 | 29-5 / 16-3 |
| Mar 21 | Arizona NCAA Third Round |
W 88-67 | 29-5 / 16-3 |
| Mar 23 | Missouri* NCAA Fourth Round |
W 81-75 | 30-5 / 17-3 |
| Mar 30 | Indiana NCAA Semifinal Round |
L 73-64 | 29-5 / 16-3 |