| DATE | OPPONENT | SCORE | RECORD/BIG 12 |
| Nov 9 | Global Sports (Exhibition) |
W 76-61 | 1-0 |
| Nov 14 | Alabama (Coaches vs. Cancer Classic - NY) |
L 68-62 | 0-1 |
| Nov 17 | Athletes First (Exhibition) |
W 100-61 | 2-0 |
| Nov 22 | UC Irvine (Sooner Invitational) |
W 87-65 | 1-1 |
| Nov 23 | Princeton (Sooner Invitational) |
W 82-63 | 2-1 |
| Nov 30 | Prairie View A&M | W 75-63 | 3-1 |
| Dec 7 | Hartford | W 92-52 | 4-1 |
| Dec 14 | Coppin State | W 69-47 | 5-1 |
| Dec 21 | Georgia State | W 89-62 | 6-1 |
| Dec 28 | Mississippi State (Sugar Bowl Classic - New Orleans) |
L 54-45 | 6-2 |
| Dec 30 | UNC Asheville | W 100-64 | 7-2 |
| Jan 4 | Michigan State (All-College Classic - Okc) |
W 60-58 | 8-2 |
| Jan 7 | Connecticut | W 73-63 | 9-2 |
| Jan 11 | Colorado* | W 69-54 | 10-2 / 1-0 |
| Jan 13 | at Oklahoma State* | L 48-46 | 10-3 / 1-1 |
| Jan 18 | at Iowa State* | W 70-60 | 11-3 / 2-1 |
| Jan 20 | Texas Tech* | W 69-64 OT | 12-3 / 3-1 |
| Jan 25 | at Baylor* | W 67-54 | 13-3 / 4-1 |
| Jan 28 | Texas A&M* | W 75-68 | 14-3 / 5-1 |
| Feb 1 | at Kansas State* | W 91-89 OT | 15-3 / 6-1 |
| Feb 8 | Baylor* | W 91-42 | 16-3 / 7-1 |
| Feb 10 | at Texas* | L 67-61 | 16-4 / 7-2 |
| Feb 15 | at Texas Tech* | W 63-58 | 17-4 / 8-2 |
| Feb 19 | Oklahoma State* | W 64-48 | 18-4 / 9-2 |
| Feb 23 | Kansas* | W 77-70 | 19-4 / 10-2 |
| Feb 26 | at Missouri* | L 67-52 | 19-5 / 10-3 |
| Mar 1 | at Texas A&M* | W 69-64 | 20-5 / 11-3 |
| Mar 5 | Nebraska* | W 76-51 | 21-5 / 12-3 |
| Mar 8 | Texas* | L 76-71 | 21-6 / 12-4 |
| Mar 13 | Bye Round 1 - Big 12 Championship* |
||
| Mar 14 | Colorado* Quarterfinals - Big 12 Championship* |
W 74-59 | 22-6 / 13-4 |
| Mar 15 | Texas Tech* Semifinals - Big 12 Championship* |
W 67-60 OT | 23-6 / 14-4 |
| Mar 16 | Missouri* Finals - Big 12 Championship* |
W 49-47 | 24-6 / 15-4 |
| Mar 20 | SC State NCAA First Round |
W 71-54 | 25-6 / 15-4 |
| Mar 22 | W 74-65 NCAA Second Round |
26-6 / 15-4 | |
| Mar 28 | Butler NCAA Regional Semifinals |
W 65-54 | 27-6 / 15-4 |
| Mar 30 | Syracuse NCAA Regional Finals |
L 63-47 | 27-7 / 15-4 |