| DATE | OPPONENT | SCORE | RECORD/BIG 12 |
| Nov 12 | Athletes First (Exh) | W 90-82 | 1-0 |
| Nov 17 | EA Sports (Exh) | W 95-73 | 2-0 |
| Nov 21 | Northwestern State | W 90-62 | 1-0 |
| Nov 26 | Colorado State Mabee Center, Tulsa |
W 82-49 | 2-0 |
| Nov 29 | Pepperdine | W 84-82 | 3-0 |
| Dec 3 | Texas-San Antonio | W 83-53 | 4-0 |
| Dec 6 | BYU Delta Center, Salt Lake City |
L 76-71 | 4-1 |
| Dec 16 | Southeastern Oklahoma State | W 93-46 | 5-1 |
| Dec 20 | at Arkansas | W 73-58 | 6-1 |
| Dec 22 | Texas-Pan American | W 96-61 | 7-1 |
| Dec 30 | Samford | W 65-50 | 8-1 |
| Jan 3 | SMU All-College Classic |
W 89-54 | 9-1 |
| Jan 6 | Texas A&M-Corpus Christi | W 84-52 | 10-1 |
| Jan 10 | at Texas Tech* | L 62-83 | 10-2 / 0-1 |
| Jan 14 | Oklahoma* | W 77-56 | 11-2 / 1-1 |
| Jan 17 | at Kansas State* | W 57-56 | 12-2 / 2-1 |
| Jan 21 | Colorado* | W 71-62 | 13-2 / 3-1 |
| Jan 24 | at Texas* | W 72-67 | 14-2 / 4-1 |
| Jan 31 | Texas Tech* | W 70-66 | 15-2 / 5-1 |
| Feb 3 | at Texas A&M* | W 91-79 | 16-2 / 6-1 |
| Feb 7 | at Iowa State* | W 88-67 | 17-2 / 7-1 |
| Feb 9 | Kansas* | W 80-60 | 18-2 / 8-1 |
| Feb 14 | Baylor* | W 91-58 | 19-2 / 9-1 |
| Feb 16 | at Oklahoma* | W 65-52 | 20-2 / 10-1 |
| Feb 21 | Nebraska* | W 87-83 OT | 21-2 / 11-1 |
| Feb 24 | at Missouri* | L 93-92 2OT | 21-3 / 11-2 |
| Feb 28 | at Baylor* | W 72-65 | 22-3 / 12-2 |
| Mar 1 | Texas* | W 76-67 | 23-3 / 13-2 |
| Mar 6 | Texas A&M* | W 70-41 | 24-3 / 14-2 |
| Mar 12 | Iowa State* Quarterfinals - Big 12 Championship |
W 83-75 | 25-3 / 15-2 |
| Mar 13 | Texas Tech* Semifinals - Big 12 Championship |
W 82-77 | 26-3 / 16-2 |
| Mar 14 | Texas* Finals - Big 12 Championship |
W 65-49 | 27-3 / 17-2 |
| Mar 19 | Eastern Washington Round 1 - NCAA Tournament |
W 75-56 | 28-3 / 17-2 |
| Mar 21 | Memphis Round 2 - NCAA Tournament |
W 70-53 | 29-3 / 17-2 |
| Mar 25 | Pittsburgh Regional Semifinals - NCAA Tournament |
W 63-51 | 30-3 / 17-2 |
| Mar 27 | St Joseph's Regional Finals - NCAA Tournament |
W 64-62 | 31-3 / 17-2 |
| Apr 3 | Georgia Tech National Semifinals - NCAA Tournament |
L 67-65 | 31-4 / 17-2 |