| DATE | OPPONENT | SCORE | RECORD/BIG 12 |
| Nov 10 | Athletes First (Exhibition) |
L 89-82 | 0-1 |
| Nov 15 | EA Sports (Exhibition) |
W 90-53 | 1-1 |
| Nov 21 | Eastern Washington Sooner Invitational |
W 69-59 | 1-0 |
| Nov 22 | Oral Roberts (Sooner Invitational) |
W 84-68 | 2-0 |
| Nov 25 | Tulsa | W 81-73 | 3-0 |
| Dec 2 | Arkansas-Pine Bluff | W 94-24 | 4-0 |
| Dec 6 | at Michigan State | W 80-77 | 5-0 |
| Dec 11 | Purdue | W 47-45 | 6-0 |
| Dec 13 | Prarie View A&M | W 83-56 | 7-0 |
| Dec 20 | Jackson State | W 68-46 | 8-0 |
| Dec 29 | Texas-Pan American | W 72-57 | 9-0 |
| Jan 3 | Princeton (All-College Classic - Okc) |
W 58-55 | 10-0 |
| Jan 11 | at Connecticut | L 59-86 | 10-1 |
| Jan 14 | at Oklahoma State* | L 56-77 | 10-2 / 0-1 |
| Jan 17 | Missouri* | L 75-79 | 10-3 / 0-2 |
| Jan 19 | at Texas Tech* | L 67-47 | 10-4 / 0-3 |
| Jan 24 | Kansas State* | W 61-49 | 11-4 / 1-3 |
| Jan 28 | at Baylor* | W 78-67 | 12-4 / 2-3 |
| Feb 1 | at Nebraska* | W 52-50 | 13-4 / 3-3 |
| Feb 4 | Iowa State* | W 75-48 | 14-4 / 4-3 |
| Feb 8 | at Texas* | L 66-37 | 14-5 / 4-4 |
| Feb 11 | Texas Tech* | W 63-48 | 15-5 / 5-4 |
| Feb 14 | at Texas A&M* | W 78-72 | 16-5 / 6-4 |
| Feb 16 | Oklahoma State* | L 65-52 | 16-6 / 6-5 |
| Feb 21 | Texas* | L 68-63 | 16-7 / 6-6 |
| Feb 25 | at Colorado* | L 94-87 OT | 16-8 / 6-7 |
| Feb 29 | at Kansas* | L 79-58 | 16-9 / 6-8 |
| Mar 3 | Texas A&M* | W 86-60 | 17-9 / 7-8 |
| Mar 6 | Baylor* | W 46-41 | 18-9 / 8-8 |
| Mar 11 | Nebraska* Round 1 - Big 12 Tournament |
W 63-59 | 19-9 / 9-8 |
| Mar 12 | Texas* Quarterfinals - Big 12 Championship |
L 66-63 | 19-10 / 9-9 |
| Mar 17 | LSU 1st Round - NIT Tournament |
W 70-61 | 20-10 / 9-9 |
| Mar 22 | at Michigan 2nd Round - NIT Tournament |
L 63-52 | 20-11 / 9-9 |