OSUOSU| DATE | OPPONENT | SCORE | RECORD/BIG 12 |
| Nov 10 | Athletes First (Ex) | W 93-80 | |
| Nov 17 | Global Sports (Ex) | W 91-63 | |
| Nov 19 | Appalachian State (America's Youth Classic) |
W 87-75 | 1-0 |
| Nov 20 | Idaho (America's Youth Classic) |
W 81-50 | 2-0 |
| Nov 23 | at Arkansas-Little Rock | W 93-64 | 3-0 |
| Nov 27 | North Texas | W 103-65 | 4-0 |
| Dec 1 | Wichita State | W 68-56 | 5-0 |
| Dec 4 | Texas-San Antonio | W 87-66 | 6-0 |
| Dec 12 | San Diego State (OKC) | W 97-63 | 7-0 |
| Dec 15 | Alcorn State | W 79-53 | 8-0 |
| Dec 18 | UNLV (Las Vegas Showdown) |
W 89-75 | 9-0 |
| Dec 21 | at Washington | W 84-72 | 10-0 |
| Dec 30 | LSU Sugar Bowl Classic |
L 63-53 | 10-1 |
| Jan 5 | Langston | W 125-65 | 11-1 |
| Jan 8 | Texas Tech* | W 55-47 | 12-1 / 1-0 |
| Jan 15 | at Baylor* | W 56-41 | 13-1 / 2-0 |
| Jan 19 | Texas* | W 73-65 | 14-1 / 3-0 |
| Jan 22 | at Texas A&M* | L 64-59 | 14-2 / 3-1 |
| Jan 26 | at Kansas State* | W 71-56 | 15-2 / 4-1 |
| Jan 30 | Baylor* | W 67-51 | 16-2 / 5-1 |
| Feb 2 | at Texas Tech* | W 63-59 | 17-2 / 6-1 |
| Feb 5 | Texas A&M* | W 87-55 | 18-2 / 7-1 |
| Feb 7 | Kansas* | W 86-53 | 19-2 / 8-1 |
| Feb 12 | at Oklahoma* | W 74-71 | 20-2 / 9-1 |
| Feb 16 | at Texas* | L 68-57 | 20-3 / 9-2 |
| Feb 19 | Nebraska* | W 94-55 | 21-3 / 10-2 |
| Feb 21 | at Missouri* | W 84-72 | 22-3 / 11-2 |
| Feb 26 | at Iowa State* | L 72-61 | 22-4 / 11-3 |
| Mar 1 | Colorado* | W 96-60 | 23-4 / 12-3 |
| Mar 4 | Oklahoma* | L 59-56 | 23-5 / 12-4 |
| Mar 10 | Round 2 - Big 12 Championship Kansas* |
W 77-58 | 24-5 / 13-4 |
| Mar 11 | Round 3 - Big 12 Championship Iowa St* |
L 68-64 | 24-6 / 13-5 |
| Mar 17 | NCAA First Round Hofstra |
W 86-66 | 25-6 / 13-5 |
| Mar 19 | NCAA Second Round Pepperdine |
W 75-67 | 26-6 / 13-5 |
| Mar 24 | NCAA Third Round Seton Hall |
W 68-66 | 27-6 / 13-5 |
| Mar 24 | NCAA Fourth Round Florida |
L 77-65 | 27-7 / 13-5 |