| DATE | OPPONENT | SCORE | RECORD/BIG 12 | Nov. 6 | El Basquetbol Mexicano (ex) | W 103-48 | Nov. 13 | Athletes First (ex) | W 92-87 | Nov. 19 | Montana State (Top of the World Classic) |
W 91-76 | 1-0 | Nov. 20 | George Washington (Top of the World Classic) |
W 73-54 | 2-0 | Nov. 21 | California (Top of the World Classic) |
W 75-58 | 3-0 | Nov. 26 | San Diego (IGA SuperThrift Sooner Holiday Classic) |
W 68-61 | 4-0 | Nov. 27 | UC Irvine (IGA SuperThrift Sooner Holiday Classic) |
W 80-68 | 5-0 | Dec. 4 | Mississippi | W 81-73 | 6-0 | Dec. 7 | at Arkansas | W 66-52 | 7-0 | Dec. 11 | Arkansas-Little Rock | W 80-56 | 8-0 | Dec. 18 | Georgia Southern | W 102-63 | 9-0 | Dec. 22 | Cincinnati | L 72-57 | 9-1 | Dec. 29 | Mt. St. Mary's (All-College Tournament) |
W 94-41 | 10-1 | Dec. 30 | Arkansas State (All-College Tournament) |
W 64-51 | 11-1 | Jan. 3 | Lamar | W 67-63 | 12-1 | Jan. 8 | Texas A&M* | W 78-53 | 13-1 / 1-0 | Jan. 11 | Baylor* | W 76-43 | 14-1 / 2-0 | Jan. 15 | at Texas* | L 79-66 | 14-2 / 2-1 | Jan. 19 | at Colorado* | L 88-80 | 14-3 / 2-2 | Jan. 22 | Iowa State* | W 80-75 2OT | 15-3 / 3-2 | Jan. 29 | at Texas Tech* | W 78-61 | 16-3 / 4-2 | Jan. 31 | Texas* | W 83-59 | 17-3 / 5-2 | Feb. 5 | at Baylor* | W 68-59 | 18-3 / 6-2 | Feb. 8 | Kansas State* | W 85-64 | 19-3 / 7-2 | Feb. 12 | Oklahoma State* | L 74-71 | 19-4 / 7-3 | Feb. 14 | at Nebraska* | W 62-54 | 20-4 / 8-3 | Feb. 20 | at Kansas* | L 53-50 | 20-5 / 8-4 | Feb. 23 | Texas Tech* | W 93-65 | 21-5 / 9-4 | Feb. 26 | Missouri* | W 83-56 | 22-5 / 10-4 | Mar. 1 | at Texas A&M* | W 77-59 | 23-5 / 11-4 | Mar. 4 | at Oklahoma State* | W 59-56 | 24-5 / 12-4 |
| Mar 10 | Round 2 - Big 12 Championship Missouri* |
W 84-80 (OT) | 25-5 / 13-4 |
| Mar 11 | Round 3 - Big 12 Championship Texas* |
W 81-65 | 26-5 / 14-4 |
| Mar 12 | Round 4 - Big 12 Championship Iowa St* |
L 70-58 | 26-6 / 14-5 |
| Mar 16 | NCAA First Round Winthrop |
W 74-50 | 27-6 / 14-5 |
| Mar 18 | NCAA Second Round Purdue |
L 66-62 | 27-7 / 14-5 |