| DATE | OPPONENT | SCORE | RECORD/BIG 12 |
| Sept 4 | Bowling Green | W 40-24 | 1-0 |
| Sept 11 | Houston | W 63-13 | 2-0 |
| Sept 18 | Oregon | W 31-7 | 3-0 |
| Oct 2 | Texas Tech* | W 28-13 | 4-0 / 1-0 |
| Oct 9 | Texas (at Dallas)* | W 12-0 | 5-0 / 2-0 |
| Oct 16 | at Kansas State* | W 31-21 | 6-0 / 3-0 |
| Oct 23 | Kansas* | W 41-10 | 7-0 / 4-0 |
| Oct 30 | at Oklahoma State* | W 38-35 | 8-0 / 5-0 |
| Nov 6 | at Texas A&M* | W 42-35 | 9-0 / 6-0 |
| Nov 13 | Nebraska* | W 30-3 | 10-0 / 7-0 |
| Nov 20 | at Baylor* | W 35-0 | 11-0 / 8-0 |
| Dec 4 | Colorado* Big 12 Championship Kansas City |
W 42-3 | 12-0 / 9-0 |
| Jan 4 | USC Fed Ex Orange Bowl 2005 National Championship |
L 55-19 | 12-1 / 9-0 |